Opportunities and challenges for microRNA-targeting therapeutics for epilepsy

RNA interference therapeutics for cancer: challenges and opportunities (review).

RNA interference (RNAi) is a sequence-specific, post-transcriptional gene silencing mechanism in animals and plants, which is mediated by double-stranded RNA (dsRNA). There has recently been an increasing interest in harnessing the gene silencing activity of dsRNA to develop novel drugs for the treatment of various diseases, such as cancer, neurol...

MicroRNA therapeutics: principles, expectations, and challenges

MicroRNAs (miRNAs) are a class of highly abundant non-coding RNA molecules that are involved in several biological processes. Many miRNAs are often deregulated in several diseases including cancer. There is substantial interest in exploiting miRNAs for therapeutic applications. In this editorial, we briefly review current advances in the use of miRNAs or antisense oligonucleotides (antagomirs) ...

New Hopes and Challenges for Treatment of Neurodegenerative Disorders: Great Opportunities for Young Neuroscientists

Islam; Challenges and Opportunities

Undoubtedly Islamic Revolution of Iran has been the source of Islamic awakening in the middle-east. Therefore Islamic Republic of Iran plays the role of an example and a director of political developments in the region. Islamic awakening in Arab countries has been able to question the dominant discourse of dictators in the middle-east region and topple their regimes. These developments include ...

MicroRNA therapeutics for cardiovascular disease

MicroRNAs (miRNAs) are short, single-stranded, noncoding RNAs that exert their function through annealing with complementary sequences in specific messenger RNAs (mRNAs) to inhibit their translation into proteins. Even though it was only a decade ago that the first human miRNA was discovered, therapeutics to regulate miRNA function are already entering the clinical space. The main reasons for t...